Illness-Death Competing Risks with Two Causes of Death

Simulates data from an illness-death model with two causes of death from the illness state. Covariate effects can be introduced via relative risk terms.

Usage

sim_multistateII(
  cumhaz,
  death.cumhaz,
  death.cumhaz2,
  n = NULL,
  rr = NULL,
  rd = NULL,
  rd2 = NULL,
  gamma23 = 0,
  gamma24 = 0,
  early2 = 10000,
  gap.time = FALSE,
  max.recurrent = 100,
  cens = NULL,
  rrc = NULL,
  extend = TRUE,
  ...
)

Arguments

cumhaz

Cumulative hazard from state 1 to 2.

death.cumhaz

Cumulative hazard of death from state 1.

death.cumhaz2

Cumulative hazard of death from state 2.

n

Number of simulations.

rr

Relative risks.

rd

Relative risks for death from state 1.

rd2

Relative risks for death from state 2.

gamma23

Early effect parameters for death causes.

gamma24

Early effect parameters for death causes.

early2

Time threshold for early effect.

gap.time

Gap time indicator.

max.recurrent

Maximum recurrent events.

cens

Censoring specification.

rrc

Censoring relative risks.

extend

Extend hazards.

...

Additional arguments.

Value

Data frame with multi-state event history.

Author

Thomas Scheike